PROCESS FOR PRODUCING AMBRISENTAN

摘要

The invention relates to a process for producing Ambrisentan (I) comprising the step of reacting (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid (II) with a 4,6-dimethyl- pyrimidine derivative (III). Furthermore, the invention relates to Ambrisentan in a crystalline form, characterized by an X-ray powder diffraction pattern with reflections at 2-theta values of approximately 8.9°, 12.3°, 17.9° and 26.9°.