<p>The present invention relates recombinant human a1-antitrypsin (rhAAT) comprising N-linked glycans, wherein at least 10% of said N-linked glycans are tetra-antennary glycans; and the degree of capping with sialic acid on said N-linked glycans (Z/A) is at least 50%.The invention further relates to rhAAT for use as a medicament, in particular for use in the prevention and/or treatment of a disease associated with AAT deficiency, and/or a disease involving neutrophil-mediated tissue damage.</p>
申请公布号
WO2010127939(A1)
申请公布日期
2010.11.11
申请号
WO2010EP55177
申请日期
2010.04.20
申请人
CRUCELL HOLLAND B.V.;BRINKMAN, ELISABETH, C., M.;HACK, CORNELIS, ERIK;VAN DEN NIEUWENHOF, INGRID
发明人
BRINKMAN, ELISABETH, C., M.;HACK, CORNELIS, ERIK;VAN DEN NIEUWENHOF, INGRID