MICROFLUIDIC ANALYTE CAPTURE USING A THERMOFLOWABLE MATERIAL

摘要

The disclosure relates to the specific capture of an analyte such as a cell from a multi-component sample, such as whole blood. Microfluidic devices contain a channel with a solid phase thermoflowable material with a binding moiety to selectively bind the analyte from the sample. After removing unbound sample components from the channel, the bound analyte can be removed from the channel by converting the thermoflowable material to a liquid phase. The analyte can be detected in the liquid thermoflowable phase, or can be separated from the liquid thermoflowable material outside the channel.