METHOD FOR MANUFACTURE OF 2-OXOIMIDAZOLIDINES

摘要

There is provided a method for manufacture of 2-oxoimidazolidines of Formula I comprising one or more of the steps of converting an amine to an acylation agent, condensation of the acylation agent with a bi-functional compound of structure L-C(R4)(R5)-C(R2)(R3)-NHR1, wherein L is a leaving group, and ring closure of the resulting urea. In this manner, certain 2-oxoimazolidines may be manufactured that are useful intermediates for the production of Pramiconazole and structurally related compounds.