| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide feline CD80, feline CD86, feline CD28, feline CTLA-4 nucleic acid and a polypeptide. <P>SOLUTION: There are provided isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86, feline CD28 or feline CTLA-4. There are also provided host cells transformed with CD80-encoding vectors, CD86-encoding vectors, CD28-encoding vectors or CTLA-4-encoding vectors; polypeptides encoded by a nucleic acid of feline CD80, feline CD86, feline CD28 or feline CTLA-4; a vaccine comprising an effective amount of polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28 or feline CTLA-4; vaccines which further comprise immunogens derived from pathogens; vaccines enhancing an immune response; and vaccines suppressing an immune response. <P>COPYRIGHT: (C)2011,JPO&INPIT |
