发明名称 |
METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR |
摘要 |
Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.
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申请公布号 |
US2010285093(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
US20100775771 |
申请日期 |
2010.05.07 |
申请人 |
SEVRAIN LIONEL C;VERDIER-SEVRAIN SYLVIE Y |
发明人 |
SEVRAIN LIONEL C.;VERDIER- SEVRAIN SYLVIE Y. |
分类号 |
A61F2/28;A61K35/32;A61P19/04;A61P43/00;C12N5/077 |
主分类号 |
A61F2/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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