发明名称 |
PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE |
摘要 |
<p>Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.</p> |
申请公布号 |
WO2010129567(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
WO2010US33571 |
申请日期 |
2010.05.04 |
申请人 |
PLEXXIKON, INC.;IBRAHIM, PRABHA, N.;SPEVAK, WAYNE;CHO, HANNA;SHI, SONGYUAN;WU, GUOXIAN |
发明人 |
IBRAHIM, PRABHA, N.;SPEVAK, WAYNE;CHO, HANNA;SHI, SONGYUAN;WU, GUOXIAN |
分类号 |
C07D471/04;A61K31/437;A61P35/02 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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