发明名称 |
Method for the treatment of neurological disorders by enhancing the activity ofβ-glucocerebrosidase |
摘要 |
Provided is a method of increasing the stability of wild-type &bgr;-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual having a neurological disease in which increased expression or activity of &bgr;-glucocerebrosidase in the central nervous system would be beneficial. This method includes administering an effective amount of a pharmacologic chaperone for &bgr;-glucocerebrosidase, with the proviso that the individual does not have a mutation in the gene encoding &bgr;-glucocerebrosidase. Further provided are &bgr;-glucocerebrosidase inhibitors which have been identified as specific pharmacologic chaperones and which have been shown to increase activity of &bgr;-glucocerebrosidase in vivo in the central nervous system.
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申请公布号 |
US7829579(B2) |
申请公布日期 |
2010.11.09 |
申请号 |
US20070768043 |
申请日期 |
2007.06.25 |
申请人 |
AMICUS THERAPEUTICS, INC. |
发明人 |
WUSTMAN BRANDON ALAN |
分类号 |
A01N43/40;A61K31/445;C07D211/00 |
主分类号 |
A01N43/40 |
代理机构 |
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