| 摘要 |
PURPOSE: A naphthoquinone derivative, and a manufacturing method thereof are provided to control the activity of DNA topoisomerase II of cancer cells, and to secure the excellent induction effect of the meronecrosis. CONSTITUTION: A manufacturing method of a naphthoquinone derivative comprises the following steps: producing N-substituted iminomethyl-1,4,5,8-tetramethoxy naphthalene compound, by reacting an oxime compound formed by reacting 2-formyl-1,4,5,8-tetramethoxynaphthalene with hydroxylamine, with iodopropane; oxidizing the outcome with CrO3 or cerium ammonium nitrate, to form 6-alkyliminomethyl-5,8-dimethoxy-1,4-naphthalenedione; and reacting the outcome with AlCl3 or dichloromethane, to form 6-propoxyiminomethyl-5,8-dihydroxy-1,4-naphthalenedione.
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