NOVEL INHIBITORS OF BETA-LACTAMASE

摘要

This invention provides novel &bgr;-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of &bgr;-lactamases and synergize the antibacterial effects of &bgr;-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the &bgr;-lactam antibiotics as a result of the presence of the &bgr;-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.