CHIMERIC L. MONOCYTOGENS IN1B PROTEIN

摘要

The invention relates to chimeric proteins having a (i) first amino acid sequence, (ii) a linker peptide, and (iii) monomer or tandem dimer of one or more domains of In1B protein (e.g., amino acids 36 to 321 of In1B). The first amino acid sequence of the chimeric protein can be the N-terminal hairpin loop of HGF. The chimeric protein may be capable of activating p42/p44 MAPK and Akt. The invention also encompasses nucleic acids and vectors encoding the chimeric protein. In addition, the invention encompasses methods of treating skin injury, lung injury, and ischemic disease by administering a pharmaceutically effective amount of a composition containing the chimeric protein.