发明名称 Renin Inhibitors
摘要 Disclosed are compounds of Formula I, wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
申请公布号 US2010280005(A1) 申请公布日期 2010.11.04
申请号 US20080450620 申请日期 2008.04.04
申请人 BALDWIN JONH J;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W;FLAHERTY PATRICK T;GHAVIMI-ALAGHA BAHMAN;GLEASON JOHN;ISHCHENKO ALEXEY V;LAWHORN BRIAN;MCGEEHAN GERARD;PATTERSON JACLYN R;SEMUS SIMON F;SIMPSON ROBERT D;SINGH SURESH B;TICE COLIN;TRAN TRITIN;XU ZHENRONG;YUAN JING;ZHAO WEI 发明人 BALDWIN JONH J.;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W.;FLAHERTY PATRICK T.;GHAVIMI-ALAGHA BAHMAN;GLEASON JOHN;ISHCHENKO ALEXEY V.;LAWHORN BRIAN;MCGEEHAN GERARD;PATTERSON JACLYN R.;SEMUS SIMON F.;SIMPSON ROBERT D.;SINGH SURESH B.;TICE COLIN;TRAN TRITIN;XU ZHENRONG;YUAN JING;ZHAO WEI
分类号 A61K31/445;A61K31/454;A61K31/4545;A61K31/4709;A61K31/496;A61K31/5377;A61K31/5415;A61K31/55;A61K31/58;A61P9/12;C07D211/60;C07D401/02;C07D413/02 主分类号 A61K31/445
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