发明名称 |
ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY |
摘要 |
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
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申请公布号 |
US2010278839(A1) |
申请公布日期 |
2010.11.04 |
申请号 |
US20100773488 |
申请日期 |
2010.05.04 |
申请人 |
PANGENETICS 110 BV |
发明人 |
POWELL JOHN;CASSON DUNCAN;MAGINN MARK;LIU WEI;DUTTA SANDEEP;BEST ANDREA;HALL JERRY A. |
分类号 |
A61K39/395;A61P25/00;C07K16/18;C12N5/10;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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