HUMANIZED ANTIBODIES THAT BIND TO CD19 AND THEIR USES

摘要

The present invention relates to humanized antibodies or fragments thereof that bind to human CD 19. More specifically, the present invention relates to a humanized antibody or fragment thereof that binds to human CD 19 comprising a heavy chain CDRl comprising the amino acid sequence of SEQ ID NO: 27, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 28, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 29; and/or comprising a light chain CDRl comprising the amino acid sequence of SEQ ID NO: 30, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 31 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 32.