发明名称 |
MODIFIED COMPSTATIN WITH PEPTIDE BACKBONE AND C-TERMINAL MODIFICATIONS |
摘要 |
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13. |
申请公布号 |
WO2010127336(A1) |
申请公布日期 |
2010.11.04 |
申请号 |
WO2010US33345 |
申请日期 |
2010.05.03 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;LAMBRIS, JOHN D.;QU, HONGCHANG |
发明人 |
LAMBRIS, JOHN D.;QU, HONGCHANG |
分类号 |
A61K38/04;C07K7/64 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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