发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING STEM CELLS AND USES THEREOF |
摘要 |
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g. satellite stem cells, to activate the planar cell polarity (PCP) pathway, thereby promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue. |
申请公布号 |
WO2010124365(A1) |
申请公布日期 |
2010.11.04 |
申请号 |
WO2010CA00601 |
申请日期 |
2010.04.27 |
申请人 |
OTTAWA HOSPITAL RESEARCH INSTITUTE;RUDNICKI, MICHAEL, A.;LE GRAND, FABIEN |
发明人 |
RUDNICKI, MICHAEL, A.;LE GRAND, FABIEN |
分类号 |
C12N5/074;A61K38/17;A61K48/00;A61P21/00;C07K14/47;C12N5/071;C12N5/077;C12N15/09;C12N15/85;C12Q1/02 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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