NEW CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER

摘要

The present invention relates to a new chlorine e6-folic acid conjugated compound, a preparation method, and a pharmaceutical composition for the treatment of cancer which contains the chlorine e6-folic acid conjugated compound. More specifically, the present invention relates to a new compound in the combined form of a chlorine e6 and a folic acid wherein the compound produces singlet oxygen effectively in various media and has a useful characteristic for the photodynamic therapy for malignant tumors due to its remarkably excellent tumor selectivity compared with conventional porphyrin photosensitizers, a preparation method thereof, and a pharmaceutical composition for treating solid cancer photodynamically which contains the chlorine e6-folic acid conjugated compound as an active ingredient.