MEANS AND METHODS FOR COUNTERACTING, PREVENTING AND/OR DETERMINING HEART FAILURE, OR A RISK OF HEART FAILURE

摘要

The present relates toa method for treating or preventing heart failure in a subject the method comprising the step of decreasing within said subject the expression, amount, and/or activity of at least one miRNA, or decreasing within said subject the interaction of at least one miRNA with its mRNA target or increasing within said subject the expression, amount, and/or activity of the mRNA target of at least one miRNA, wherein said at least one miRNA is selected from the group consisting of miR-191*, miR-15b, miR-1228*, miR-181a, miR-18a*, miR-107, miR-299- 3p, mi R-342-3p, and miR-652..