发明名称 |
METHODS FOR TREATING MOTOR NEURON DISEASE |
摘要 |
An object of the present invention is to provide an agent effective for the treatment and/or prevention of motor neuron disease such as amyotrophic lateral sclerosis (ALS). The present invention provides a therapeutic and/or preventive agent for motor neuron disease comprising the following oligopeptide shown in any of (a) to (c) or a pharmaceutically acceptable salt thereof as an active ingredient: (a) an oligopeptide consisting of the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1); (b) an oligopeptide consisting of an amino acid sequence having a deletion, substitution, insertion, or addition of one or several amino acids in Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death caused by a mutant superoxide dismutase-1 gene; and (c) a modified oligopeptide from the oligopeptide (a) or (b).
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申请公布号 |
US2010279942(A1) |
申请公布日期 |
2010.11.04 |
申请号 |
US20100755809 |
申请日期 |
2010.04.07 |
申请人 |
CHIBA TOMOHIRO;KITA YOSHIKO;MATSUOKA MASAAKI;TERASHITA KENZO;AISO SADAKAZU;NISHIMOTO IKUO;NISHIMOTO TOMO |
发明人 |
CHIBA TOMOHIRO;KITA YOSHIKO;MATSUOKA MASAAKI;TERASHITA KENZO;AISO SADAKAZU;NISHIMOTO IKUO;NISHIMOTO TOMO |
分类号 |
A61K38/08;A61K38/00;A61K38/16;A61P25/00;A61P25/02;A61P25/28;C07K7/06;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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