Malaria is a vector borne infectious disease caused by protozoan parasites. Oil based arteether injections are used as anti-malarial drugs, specifically for the treatment of chloroquine resistant Plasmodium falciparum malaria and cerebral malaria cases. Arteether is a fast acting blood schizontocide. The injectable formulation of arteether contains a mixture of ethyl oleate and ethyl alcohol in specific concentrations to reduce the viscosity and the filling volume of the product. This creates minimum muscle pain and muscle stiffness because a higher concentration of arteether (150 mg) is present in a small volume of injectable solution (1 ml). Other pharmaceutical excipients like antioxidants and preservatives are also used in the formulation.
申请公布号
WO2010082219(A3)
申请公布日期
2010.11.04
申请号
WO2009IN00757
申请日期
2009.12.30
申请人
LINCOLN PHARMACEUTICALS LIMITED;PATEL, RAJANI GULABDAS;SHAH, ARUN CHIMANLAL;PATEL, JIGAR HASMUKHBHAI