PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY

摘要

This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.