| 摘要 |
PROBLEM TO BE SOLVED: To provide a tumor-specific mutant of B-Raf gene, a method for diagnosing tumor, and a method for developing therapeutic drugs for treating tumor. SOLUTION: Mutations described are identified in human tumors, wherein the mutations are seen in a natural mutant human B-Raf polypeptide comprising one or more amino acid mutations in tumor-associated somatic cells. These mutations are associated with cancerous phenotypes and can be used for a method for detecting carcinogenic mutations by inspecting nucleic acid substances derived from at least a part of B-Raf genes in human subjects, a method for detecting mutant B-Raf polypeptides using antibodies, and further the development of anti-cancer therapeutics on the basis of a method for identifying one or more compounds having anti-proliferation activity. COPYRIGHT: (C)2011,JPO&INPIT
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