| 发明名称 |
MODIFIED TRNA CONTAINING NON-NATURAL NUCLEOTIDE AND USE THEREOF |
| 摘要 |
<p>In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the efficiency of aminoacylation of the tRNA with a noncanonical amino acid can be improved.</p> |
| 申请公布号 |
EP2246428(A1) |
申请公布日期 |
2010.11.03 |
| 申请号 |
EP20090709377 |
申请日期 |
2009.02.03 |
| 申请人 |
THE UNIVERSITY OF TOKYO;RIKEN |
发明人 |
SEKINE, SHUN-ICHI;FUKUNAGA, RYUYA;YOKOYAMA, SHIGEYUKI;HIRAO, ICHIRO;HARADA, YOKO |
| 分类号 |
C12N15/09;C07H21/02;C12N9/10;C12P21/00;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/573 |
主分类号 |
C12N15/09 |
| 代理机构 |
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