发明名称 |
PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN 1 LOOP 2 OR 2 LOOP 1 OF AN ADRENORECEPTOR |
摘要 |
A peptide having an ED 50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular ±1 loop 2 or ²2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of ³-secretase activity, an increased release of ²-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED 50 value is measured by bioassay. |
申请公布号 |
EP2244718(A2) |
申请公布日期 |
2010.11.03 |
申请号 |
EP20090702027 |
申请日期 |
2009.01.15 |
申请人 |
MDC MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZINBERLIN - BUCH;KUNZE, RUDOLF |
发明人 |
KUNZE, RUDOLF;WALLUKAT, GERD;ROSENTHAL, PETER;STRAUBE, RICHARD |
分类号 |
A61K38/00;A61K38/08;A61P25/28;C07K1/22;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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