发明名称 |
APPARATUS AND METHOD FOR DELIVERY OF MITOMYCIN THROUGH AN ELUTING BIOCOMPATIBLE IMPLANTABLE MEDICAL DEVICE |
摘要 |
The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device. A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug incorporated into the biocompatible drug release matrix. The drug has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug release rate maintains tissue level concentrations of the drug for at least two weeks after implantation of the medical device. The present invention provides a coating for a vascular prosthesis that elutes the drug at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis. |
申请公布号 |
EP1549253(A4) |
申请公布日期 |
2010.11.03 |
申请号 |
EP20030798778 |
申请日期 |
2003.09.26 |
申请人 |
ENDOVASCULAR DEVICES, INC. |
发明人 |
GRANADA, JUAN, F.;FURNISH, SIMON, M. |
分类号 |
A61F2/00;A61F2/06;A61F2/84;A61F2/90;A61K31/407;A61K47/30;A61L27/34;A61L27/54;A61M;B05D3/00;(IPC1-7):A61F2/06 |
主分类号 |
A61F2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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