发明名称 |
NOVEL BETULINIC ACID DERIVATIVES A-RING-CONDENSED TO A HETEROCYCLIC GROUP |
摘要 |
<p>The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.</p> |
申请公布号 |
EP1858910(B1) |
申请公布日期 |
2010.11.03 |
申请号 |
EP20050850957 |
申请日期 |
2005.12.29 |
申请人 |
DABUR PHARMA LTD. |
发明人 |
MUKHERJEE, RAMA;SRIVASTAVA, SANJAY K.;SIDDIQUI, MOHAMMAD J.A.;JAGGI, MANU;SINGH, ANU T.;VARDHAN, ANAND;SINGH, MANOJ KUMAR;RAJENDRAN, PRAVEEN;JAJOO, HEMANT KUMAR;BURMAN, ANAND C.;KUMAR, VIVEK;RANI, NIDHI;AGARWAL, SHIV KUMAR |
分类号 |
C07J71/00;A61K31/58;A61P35/00 |
主分类号 |
C07J71/00 |
代理机构 |
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代理人 |
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