METHOD FOR PREPARING TAXANE DERIVATIVES

摘要

PURPOSE: A method for manufacturing taxane derivative is provided to reduce production cost of side chain using mixture of chiral isomer without separation. CONSTITUTION: A method for preparing taxane derivative of chemical formula I comprises: a step of condensing baccatin III or 10-deacetyl baccatin III derivative of chemical formula III to 7th and/or 10th hydroxyl group and side chain selected from mixture of (2S,3S)-phenylisoserine derivative of chemical formula IIb and (2R,3S)-phenyl isoserine derivative of chemical formula IIa to obtain mixture of compounds of chemical formula IVa and chemical formula IVb; a step of removing protection group of side chain of the mixture to obtain a mixture of compounds of chemical formula Va and Vb; a step of performing chromatography to obtain isomeric compound; and a step of removing 7th and/or 10th protection group.