OPTIMIZED CD40 ANTIBODIES AND METHODS OF USING THE SAME
摘要
<p>The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcgammaR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.</p>
申请公布号
EP2245065(A1)
申请公布日期
2010.11.03
申请号
EP20090703152
申请日期
2009.01.21
申请人
XENCOR, INC.
发明人
BERNETT, MATTHEW J.;CHU, SEUNG YUP;DESJARLAIS, JOHN R.;KARKI, SHER BAHADUR;LAZAR, GREGORY ALAN;PONG, ERIK WEIKING;ZHUKOVSKY, EUGENE ALEXANDER
