发明名称 |
Delivery of proteins across polar epithelial cell layers |
摘要 |
This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to α2 macroglobulin receptor α2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.
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申请公布号 |
US7824695(B1) |
申请公布日期 |
2010.11.02 |
申请号 |
US20000110880 |
申请日期 |
2000.10.18 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;GENENTECH, INC. |
发明人 |
FITZGERALD DAVID J.;MRSNY RANDALL J.;MCKEE MARIAN;DAUGHERTY ANN |
分类号 |
A61K39/108;C12N15/09;A61K9/12;A61K9/20;A61K9/48;A61K38/00;A61K38/21;A61K38/27;A61K38/28;A61K39/38;A61K39/395;A61K45/00;A61K47/26;A61K47/42;A61K47/44;A61K47/48;A61P3/10;A61P31/00;A61P37/02;C07H21/02;C07K1/00;C07K14/21;C07K16/18;C07K19/00;G01N1/00;G01N33/554 |
主分类号 |
A61K39/108 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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