Novel hydroxy functionalized 1,2,4-trioxanes as antimalarial agents and a process for the preparation thereof.

摘要

The present invention relates to novel hydroxy functionalized 1, 2, 4-trioxanes of general formula (7) useful as antimalarial agents. This invention also relates to a process for the preparation of novel hydroxy functionalized 1, 2, 4- trioxanes and their derivatives. More particularly the present invention provides a process for the preparation of hydroxy functionalized 1, 2, 4-trioxanes and their derivatives of general formula (7) wherein R1 and R2 represents methyl, or part of a cyclic system such as cyclopentane, cyclohexane, cycloheptane, adamantane and A is a spacer such as oxygen substituted aromatic moieties and R3 is CH2CH2OH or CH2CH2OCOCH2CH2COOH.These novel hydroxy functionalized 1, 2, 4-trioxanes and their derivatives of general formula (7) are new compounds and are useful as antimalarial agents. These compounds have been tested against multi-drug resistant malaria in mice and have shown promising antimalarial activity. This invention, thus relates to pharmaceutical industry.