发明名称 |
Antisense modulation of insulin-like growth factor binding protein 5 expressions |
摘要 |
<p>Provided is an antisense oligonucleotide 8 to 50 nucleobases in length targeted to nucleobases 11 through 30 or nucleobases 584 through 603 of a specified sequence of the nucleic acid molecule encoding insulin-like growth factor binding protein 5, wherein said oligonucleotide specifically hybridizes with one of said regions and inhibits the expression of insulin-like growth factor binding protein when the antisense molecule has at least a 70% complementary sequence to the said targeted nucleobases. The molecule can be used in vitro to inhibit the insulin-like growth factor binding protein 5 in cells or tissues.</p> |
申请公布号 |
NZ577565(A) |
申请公布日期 |
2010.10.29 |
申请号 |
NZ20020577565 |
申请日期 |
2002.10.07 |
申请人 |
ISIS PHARMACEUTICALS, INC |
发明人 |
FREIER, SUSAN M |
分类号 |
C12Q1/68;A61K31/7088;A61K38/00;C07H21/04;C12N15/09;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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