MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF SHORT INTERFERING RIBONUCLEIC ACID (SIRNA) BY NUCLEOTIDE MODIFICATION
摘要
<p>Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2' sugar modifications and,optionally, intemucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention. No suitable figure.</p>
申请公布号
SG165394(A1)
申请公布日期
2010.10.28
申请号
SG20100067445
申请日期
2006.09.15
申请人
COLEY PHARMACEUTICAL GMBH;QIAGEN GMBH
发明人
UHLMANN, EUGEN;JURK, MARION;VOLLMER, JOERG;SCHETTER, CHRISTIAN;WEBER, MARTIN;ANDREOU, IOANNA;PITSCH, STEFAN