发明名称 |
CARBOXYLIC ACID COMPOUND |
摘要 |
Disclosed is a compound having a GPR40 agonistic activity and useful for use in a pharmaceutical composition or useful as an insulin secretion promoter or a prophylactic or therapeutic agent for diabetes. Extensive studies have been made on compounds having a GPR40 agonistic activity. As a result, it is found that a compound (I) having a carboxylic acid bound to the second or third ring moiety through a methylene group or having a benzene ring bound to the second or third ring moiety through a group O-methylene -NH-methylene, wherein the benzene ring has been substituted by a 6-membered monocyclic aromatic ring, or a pharmaceutically acceptable salt of the compound (I) has an excellent GPR40 agonistic activity. It is also found that the compound has an excellent insulin secretion-promoting activity and can prevent the increase in a blood glucose level after glucose tolerance aggressively.
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申请公布号 |
CA2759690(A1) |
申请公布日期 |
2010.10.28 |
申请号 |
CA20102759690 |
申请日期 |
2010.04.21 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
NEGORO, KENJI;OHNUKI, KEI;YONETOKU, YASUHIRO;KURAMOTO, KAZUYUKI;URANO, YASUHARU;WATANABE, HIDEYUKI |
分类号 |
C07C43/225;A61K31/40;A61K31/4015;A61P3/10;C07C49/417;C07C69/76;C07C235/18;C07C303/36;C07D207/06;C07D207/27;C07D239/34;C07D305/06;C07D307/94;C07D309/06;C07D309/10;C07D317/22;C07D405/12;C07K14/705;C12N15/09 |
主分类号 |
C07C43/225 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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