发明名称 |
POLYVALENT CHIMERIC RUBELLA VIRUS-BASED VACCINES |
摘要 |
A chimeric viral particle that comprises a RV fusion gene is disclosed. The RV fusion gene comprises a first nucleotide sequence encoding a RV that is devoid of RV E1 protein, and a second nucleotide sequence that linked in translation frame to the first nucleotide sequence and encodes a humoral immunogenic viral protein. The chimeric viral particle is free of RV E1 protein-encoding gene. A virus packaging cell that generates the chimeric viral particle comprising a RV fusion gene and an isolated expression vector comprising a RV fusion gene linked in translation frame to a promoter are also disclosed.
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申请公布号 |
US2010272747(A1) |
申请公布日期 |
2010.10.28 |
申请号 |
US20100763801 |
申请日期 |
2010.04.20 |
申请人 |
NATIONAL HEALTH RESEARCH INSTITUTES |
发明人 |
CHOW YEN-HUNG;SIA CHARLES DWO-YUAN;CHONG PELE CHOI-SING;HSIAO KUANG-NAN |
分类号 |
A61K39/12;A61P31/12;A61P37/04;C12N7/01;C12N15/74 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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