发明名称 |
BLOCKERS OF NMDA RECEPTOR FOR THE TREATMENT OF SICKLE CELL ANEMIA |
摘要 |
Sickle cell anemia is a genetic disease characterized by red blood cells that assume an abnormal, rigid, sickle shape. Acute complications of Sickle cell anemia are treated symptomatically with analgesics and transfusions, and a prophylactic treatment of sickle cell crisis is long term application of hydroxyurea. According to the present invention, an N-methyl D-aspartate receptor (NMDAR) blocker is used for the treatment of sickle cell anemia and for manufacture of a medicament for the treatment of sickle cell anemia. Moreover, a method for screening for a compound effective in the treatment of sickle cell anemia comprises contacting a candidate compound with the NMDAR and selecting said candidate compound as effective if it is found to selectively reduce activity of the NMDAR. |
申请公布号 |
WO2010121973(A1) |
申请公布日期 |
2010.10.28 |
申请号 |
WO2010EP55077 |
申请日期 |
2010.04.18 |
申请人 |
UNIVERSITAET ZUERICH;BOGDANOVA, ANNA, YULIENVA;GASSMANN, MAX;GOEDE, JEROEN |
发明人 |
BOGDANOVA, ANNA, YULIENVA;GASSMANN, MAX;GOEDE, JEROEN |
分类号 |
A61K31/00;A61K31/13;A61K31/4468;A61P7/00;A61P7/06 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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