| 摘要 |
<p>The present invention relates to a biphenyl compound represented by the formula (100) wherein R1Æ is hydrogen, C1-C6 alkyl, halogen, halo C1-C6 alkyl or C1-C6 alkoxy; R 2ÆÆÆ is hydrogen, C1-C6 alkyl, halogen, halo C1-C6 alkyl or C2-C6 alkenyl; R 3 " is -CON(R11a) (R12a) wherein R11a and R12a are each independently hydrogen, C1-C6 alkyl, optionally substituted C6-C14 aryl, optionally substituted C7-C16 aralkyl, C1-C6 alkoxy, or R11a and R12a may be taken together with the nitrogen to which they are attached to form in which p is an integer of 0 to 2; R4'is hydrogen, halogen, C1-C6 alkyl or halo C1-C6 alkyl; R50 is hydrogen, C1-C6 alkyl, optionally substituted C6-C14 aryl or optionally substituted C7-C16 aralkyl; and 1a is an integer of 1 to 3, or a prodrug thereof, or a pharmaceutically acceptable salt of either. The biphenyl compound of the present invention is an intermediate compound, which can be used as a starting compound for the end product, for example, pharmaceutically active compound, e.g. ester compound (1):</p> |
