SENSORY-SPECIFIC LOCAL ANESTHESIA AND PROLONGED DURATION LOCAL ANESTHESIA
摘要
Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block over motor block. The duration of block is greatly prolonged by combining the local anesthetic with a permeation enhancer. The selectivity of sensory over motor block is provided by selecting the concentration of the local anesthetic and the permeation enhancer to provide selective permeability of the sensory and motor neurons to the enhancer.
申请公布号
WO2009143175(A3)
申请公布日期
2010.10.28
申请号
WO2009US44549
申请日期
2009.05.19
申请人
CHILDREN'S MEDICAL CENTER CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;KOHANE, DANIEL, S.;SAGIE, ITAY