PROCESS FOR PRODUCTION OF 2-AZAADAMANTANE COMPOUND FROM BICYCLOCARBAMATE COMPOUND

摘要

Disclosed is a novel process for producing a 2-azaadamantane compound from a bicyclocarbamate compound. A 2-azaadamantane compound represented by formula (3) can be produced by a process represented by scheme (I), wherein the process comprises: reacting a bicyclocarbamate compound represented by formula (1) with a halogenating agent to produce a 2-azaadamantane carbamate compound represented by formula (2); and hydrogenolyzing the 2-azaadamantane carbamate compound to produce the 2-azaadamantane compound represented by formula (3). (In the formulae, R1 represents a hydrogen atom, or the like; R2 and R3 independently represent a hydrogen atom, or a C1-6 alkyl group; Ar represents an aryl group which may be substituted by Ra; Ra represents a halogen atom, or the like; X represents a halogen atom; and Y represents X or a hydrogen atom.)