摘要 |
<p>Methyl cantharimide compounds, the treatment method using them and their preparation method are disclosed. The methyl cantharimide compounds contain the main chain as shown by the following formula (I): wherein R1, R2, R3 and R4 are respectively selected from H, C(O)OR5, C(O)R6, C(O)NR7R8, NR9C(O) R10, N-R11R12, O-R13, S-R14, P(O) (OR15) (OR16), As(O) (OR17) (OR18), SO2R19, SO3R20 and B(OR21); X1-X4 are respectively selected from nitrogen or carbon; R1-R4 are not all hydrogen; Y1, Y2 and R5-R21 are respectively selected from hydrogen, C1-12 alkyl, aryl, heterocyclic group and a bioactive polymer. The methyl cantharimide compounds of the invention have lower cytotoxicity to normal cells and have higher cytotoxicity to cancer cells.</p> |
申请人 |
THE HONG KONG POLYTECHNIC UNIVERSITY;CHAN, ALBERT, SUN-CHI;TANG, JOHNNY, CHEUK-ON;LAM, KIM-HUNG;CHUI, CHUNG-HIN;KOK, STANTON HON LUNG;YUEN, MARCUS CHUN WAH;CHAN, SAU HING;CHENG, CHOR HING;CHEUNG, FILLY |
发明人 |
CHAN, ALBERT, SUN-CHI;TANG, JOHNNY, CHEUK-ON;LAM, KIM-HUNG;CHUI, CHUNG-HIN;KOK, STANTON HON LUNG;YUEN, MARCUS CHUN WAH;CHAN, SAU HING;CHENG, CHOR HING;CHEUNG, FILLY |