发明名称 |
MODIFIED CIPA GENE FROM CLOSTRIDIUM THERMOCELLUM FOR ENHANCED GENETIC STABILITY |
摘要 |
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms. |
申请公布号 |
CA2759245(A1) |
申请公布日期 |
2010.10.28 |
申请号 |
CA20102759245 |
申请日期 |
2010.04.21 |
申请人 |
THE TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
CURRIE, DEVIN HEDLEY;MCBRIDE, JOHN;GUSS, ADAM |
分类号 |
C12N15/31;C12N1/21;C12N15/00;C12N15/74;C12P7/10 |
主分类号 |
C12N15/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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