| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to novel malonamide derivatives of general formula , to their pharmaceutically acceptable salts of acid bonding and to all forms of their optically pure enantiomers, racemates or diastereomers and diastereomer mixtures, possessing inhibiting activity with respect to -secretase, as well as to pharmaceutical preparation, containing one or more than one of claimed compounds, and to application of claimed compounds for manufacturing of drugs. Values of substituents R, R1, R2, R3, as well as X, n are given in invention formula. ^ EFFECT: obtaining compounds that can be applied in treatment of Alzheimer's disease. ^ 19 cl, 6 dwg, 111 ex |
