| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel biologically active compounds of formula , where substitutes R, R1, R2 and R3 are defined in the formula of invention, and can be obtained using a method which involves reaction of corresponding chloroacetamides with a prepared solution of elementary sulphur with morpholine or piperidine, passing the obtained solution of monothiooxamides through a layer of sorbent and then reaction of monothiooxamides with hydrazine-hydrate, reaction of the obtained compound with aldehydes in dimethyl formamide at room temperature and precipitation with methanol which gives good output of the end product. ^ EFFECT: obtained compounds are highly effective against pathogenic bacteria, are characterised by selectivity and can be used to inhibit type III secretion in pathogenic bacteria. ^ 3 cl, 8 dwg, 1 tbl, 21 ex |
