| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel compounds of formula I , in which A denotes hydrogen, B denotes methyl or B is in a trans-position relative oxygen; X denotes CH2; Y denotes a group of formula , , , ^ , or ; ^ , in which the left-hand bond is to an oxygen atom, and the right-hand bond is to the group R; R denotes 5-indolyl; in form of a free base or an acid addition salt. The invention also relates to a pharmaceutical composition, to use of compounds in any of claims 1-7, to a method of preventing and treating psychiatric and neurodegenerative disorders in a person, as well as a method of treating and preventing diseases or pathological condition in which 7 nAChR activation plays a role. ^ EFFECT: obtaining novel biologically active compounds having 7 nAChR agonist activity. ^ 16 cl, 4 ex |
