METHYL 4-3[(3,4-DICHLOROPHENYL)ACETYL-3-[(1-PYRROLIDINYL)METHYL]-1-PIPERAZINE CARBOXYLATE SYNTHESIS METHOD

摘要

FIELD: chemistry. ^ SUBSTANCE: method of producing opiate k-receptor agonist 4-[(3,4-dichlorophenyl)acetyl-3-[(1-pyrrolidinyl)methyl-1-piperazine carboxylate which has high affinity to k- opioid receptors. Lack of methods for synthesis of compounds of this class, which restricts their wide use, while their synthesis methods described in literature involve several steps which results in low output of the desired product. ^ EFFECT: cutting on the number of steps during synthesis of the desired compound and higher output of the product. ^ 1 cl, 3 dwg, 1 tbl, 6 ex