发明名称 |
DEVICES AND METHODS FOR ELUTION OF NUCLEIC ACID DELIVERY COMPLEXES |
摘要 |
<p>Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.</p> |
申请公布号 |
EP2242520(A2) |
申请公布日期 |
2010.10.27 |
申请号 |
EP20090701940 |
申请日期 |
2009.01.14 |
申请人 |
SURMODICS, INC. |
发明人 |
JOHNSON, ELIZABETH, E.;ANDERSON, ARON, BRENT;MCGONIGLE, JOSEPH, SCHMIDT |
分类号 |
A61L27/22;A61L27/34;A61L27/50;A61L27/54;A61L31/04;A61L31/10;A61L31/14;A61L31/16 |
主分类号 |
A61L27/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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