发明名称 |
Process for the preparation of chiral 8-(-3-aminopiperidin-1-yl) xanthines |
摘要 |
The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. The process involves reacting a compound of the formula (III) with 3-(phthalimido)piperidine or an enantiomer thereof where X is a leaving group selected from halogens and sulphonic ester acid residues, and R1 to R3 are as defined herein, to obtain a compound of the formula (II) and deprotecting the obtained compound of the formula (II) to obtain the product xanthines.
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申请公布号 |
US7820815(B2) |
申请公布日期 |
2010.10.26 |
申请号 |
US20050267235 |
申请日期 |
2005.11.04 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
PFRENGLE WALDEMAR;PACHUR THORSTEN;NICOLA THOMAS;DURAN ADIL |
分类号 |
C07D473/06;C07D401/04 |
主分类号 |
C07D473/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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