发明名称 |
RECOMBINANT FUSION PROTEIN PRODUCED BY FUSING VIBRIO VULNIFICUS FLAGELLIN AND PATHOGENIC ANTIGENS AND THE MUCOSAL VACCINE CONTAINING THE SAME AS AN ACTIVE INGREDIENT |
摘要 |
PURPOSE: A recombinant fusion protein prepared by fusing antigen of pathogen with vaccine adjuvant and a vaccine for mucosal administration is provided to enhance PspA-specific antibody(IgG and IgA) generation. CONSTITUTION: A recombinant fusion protein is prepared by fusing protein antigen of pathogen with flagellin protein of Vibrio vulnificus. The flagellin is a FlaB of Vibrio vulnificus of sequence number 1. The antigen of pathogen is an alpha-helix domain and surface adhesion factor A(PsaA) of Streptococcus pneumoniae surface protein A(PsaA); subunit HA(hemagglutinin) and NA(neuraminidase) of influenza virus; or spike(S) protein of SARS virus. A vaccine for mucosal administration contains the recombinant fusion protein as an active ingredient.
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申请公布号 |
KR20100114620(A) |
申请公布日期 |
2010.10.26 |
申请号 |
KR20090033083 |
申请日期 |
2009.04.16 |
申请人 |
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY |
发明人 |
RHEE, JOON HAENG;LEE, SHEE EUN;KIM, SOO YOUNG;TRUONG CHUNG NGUYEN |
分类号 |
C07K19/00;A61K39/106;C07K14/28 |
主分类号 |
C07K19/00 |
代理机构 |
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