| 发明名称 |
AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS |
| 摘要 |
A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.
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| 申请公布号 |
CA2412164(C) |
申请公布日期 |
2010.10.26 |
| 申请号 |
CA20012412164 |
申请日期 |
2001.06.14 |
| 申请人 |
MERCK SHARP AND DOHME LIMITED |
发明人 |
CURTIS, NEIL ROY;KULAGOWSKI, JANUSZ JOZEF;THOMAS, STEVE;WATT, ALAN PAUL |
| 分类号 |
C07C257/14;C07D333/20;A61K31/155;A61K31/341;A61K31/381;A61K31/4409;A61P9/00;A61P9/10;A61P21/02;A61P25/00;A61P25/04;A61P25/08;A61P25/22;A61P25/28;A61P29/02;A61P43/00;C07D213/36;C07D213/40;C07D307/52;C07D333/14 |
主分类号 |
C07C257/14 |
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