Ligand-coupled initiator polymers and methods of use

摘要

Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreaticβcells and can be used to encapsulate cells for transplantation and the treatment of diabetes.