METHOD FOR PREPARATION OF γ-THUJAPLICIN

摘要

PURPOSE: A producing method of gamma-thujaplicin is provided to economically and simply produce the gamma-thujaplicin with the high yield. CONSTITUTION: A producing method of gamma-thujaplicin comprises the following steps: forming cyclopentadienyl sodium by reacting cyclopentadiene and sodium amide inside an N,N-dimethylformamide solution; reacting an isopropylating agent with the cyclopentadienyl sodium to obtain an isopropyl cyclopentadiene compound; obtaining a mixture of a 7,7-dichlorobicyclo[3.2.0]-hept-2-en-6-on derivative; solvent decomposing the mixture of a 7,7-dichlorobicyclo[3.2.0]-hept-2-en-6-on derivative; and separating the gamma-thujaplicin from a crude product.